Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats.
نویسندگان
چکیده
منابع مشابه
Behavior After Brain Infarction in Rats
Background and Purpose: Functional tests that are stable and consistent over time are an advantage for long-term evaluation of treatment in experimental stroke research. Because little information on this subject is available in rodents with focal cerebral ischemia, we investigated the outcome of three behavioral tests for a period of 3 months after the insult. Methods: Spontaneously hypertensi...
متن کاملMotor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats.
BACKGROUND AND PURPOSE Exercise and rehabilitative training each have been implicated in the promotion of restorative neural plasticity after cerebral injury. Because motor skill training induces synaptic plasticity and exercise increases plasticity-related proteins, we asked if exercise could improve the efficacy of training on a skilled motor task after focal cortical lesions. METHODS Femal...
متن کاملDonepezil and Rivastigmine: Pharmacokinetic Profle and Brain-targeting After Intramuscular Administration in Rats
Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...
متن کاملDonepezil and Rivastigmine: Pharmacokinetic Profle and Brain-targeting After Intramuscular Administration in Rats
Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...
متن کاملBrain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats.
BACKGROUND AND PURPOSE Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment and exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the beneficial effects of rehabilitation in promoting recov...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 1993
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.24.6.889